HSL/2006/108-Core Activity on Aldehyde Measurement and Analysis

Gender differences in hormone-sensitive lipase expression, activity and phosphorylation in skeletal muscle at rest and during exercise

Women have been shown to use more intramuscular triacylglycerol (IMTG) during exercise compared with men. To investigate whether this could be due to gender-specific regulation of HSL and to use gender-comparison as a model to gain further insight into HSL regulation, nine women and eight men performed bicycle exercise (90 min, 60% VO2 peak), and skeletal muscle HSL expression, phosphorylation,...

Regulation of HSL serine phosphorylation in skeletal muscle and adipose tissue.

Hormone-sensitive lipase (HSL) is important for the degradation of triacylglycerol in adipose and muscle tissue, but the tissue-specific regulation of this enzyme is not fully understood. We investigated the effects of adrenergic stimulation and AMPK activation in vitro and in circumstances where AMPK activity and catecholamines are physiologically elevated in humans in vivo (during physical ex...

HSL/2006/40 - Final report on JS2002837 Measurement of HCl in workplace air

Adrenergic regulation of HSL serine phosphorylation and activity in human skeletal muscle during the onset of exercise.

Skeletal muscle hormone-sensitive lipase (HSL) activity is increased by contractions and increases in blood epinephrine (EPI) concentrations and cyclic AMP activation of the adrenergic pathway during prolonged exercise. To determine the importance of hormonal stimulation of HSL activity during the onset of moderate- and high-intensity exercise, nine men [age 24.3 +/- 1.2 yr, 80.8 +/- 5.0 kg, pe...

On the Direct Solution of Very Large Sparse Linear Systems Using Out-of-core Techniques

An effective way of extending the size of problem that can be successfully solved using a sparse direct solver is to allow the system matrix and its factors to be held out-of-core. In this talk, we discuss the design and development of new sparse out-of-core solvers that will be included in the next release of the HSL mathematical software library [1]. An important feature of the codes is that ...